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PRODUCT INFORMATION MARKHERB®
MITRAGYNINE
Kratom leaves contain more than 40 types of alkaloid compounds beneficial to the body, including Mitragynine, 7-hydroxymitragynine, Speciociliatine, Corynantheidine, Speciogynine, Paynantheine, dan Mitraphylline. The most well-studied compounds related to kratom are mitragynine and 7-hydroxymitragynine. The two compounds are known to interact with opioid receptors in the brain. Both activate mu-opioid receptors (specific molecular structures on the surface of nerve cells), but the resulting effects only partially compare to those of opioids like hesroin or oxycodone10. Compared to Methadone, Mitragynine provides longer-lasting effects and has lower toxicity due to its more stable binding to the mu-opioid receptors.
Some research suggests that Mitragynine and 7-hydroxymitragynine may not cause some of the more serious adverse effects associated with opioid use such as respiratory depression (trouble breathing) that can occur during a life-threatening opioid overdose. Scientists also have observed that Mitragynine may bind to adrenergic receptors, serotonin receptors and dopamine receptors, which may be responsible for some of the arousing effects some people who use kratom report experiencing.
PRODUCT INFORMATION MARKHERB® MIT 20-90
Suspected Health Benefits of Kratom
Kratom for Pain
Kratom may be effective for easing chronic pain, as it works by attaching to opioid receptors. One compound found in kratom, 7-hydroxymitragynine, is 13 times more potent than morphine. Although kratom targets opioid receptors just like morphine and codeine do, it is considered an atypical opioid. Kratom selectively inactivates specific signals, which may explain the more tolerable side effects compared to typical opioids.
Kratom for Mood Boosting
Kratom may have mood-enhancing effects. Some reports suggest that kratom may be an effective treatment for opioid addiction. Some people use it to help ease the withdrawal symptoms of morphine and ethanol. Early studies suggest that kratom may have potential as an antidepressant and a hunger suppressant. In one animal study, researchers determined that kratom lowers corticosterone levels in mice. Increased corticosterone levels are just one of the changes in brain chemicals that can be seen in depression. Furthermore, in another study with rats, kratom supplementation suppressed hunger by inhibiting the hypothalamus, the part of the brain responsible for appetite and cravings. More research on humans is needed to see if kratom has similar effects.
Kratom for Opiate Withdrawal
Some people have reported that kratom can help with self-treatment of opioid withdrawal symptoms. It has also been promoted as a remedy or cure for opioid addiction. But there’s no approved use of kratom for these purposes. Experts need to look deeper into this to understand if it can actually help with withdrawal.